SasuHina? My first thought was, “Does that even exist?” lol. I don’t think it would work out, for three basic reasons based on his own pattern and personality.
SasuKarin i find more basis for. I think she does love him, but i also think she underestimated the force of his focus and determination. No vagina is going to lead him astray. Period. I also think he was genuinely using her for exactly what he said he needed her for: her skills. But i think i favor them more because Karin has been on a part of Sasuke’s journey with him and has seen him in a few of his weak moments. In other words, she has a better understanding of him. The Uzumaki connection is hysterical to me, and a nice touch from Kishi tbh. The Uzumaki and Uchiha will be forever linked.
SasuSaku…my opinion on them is pretty unshakable at this point still, in the sense that i do not believe she understands him now. Like, at all. I also find her love a bit blind, as she maintains this image of him that he in reality left behind a longtime ago. However, if they wound up together, i wouldn’t shed tears of blood. They are much more acceptable to me than SasuHina for example. For me, i’d just be happy if Sasuke was back in Team 7 in the arms of his whole former team, and not just condense it to the typical love scene. I do not recall the comment you are mentioning though.